Association between fatty liver and type 2 diabetes in the baseline population of Jinchang Cohort.
10.3760/cma.j.issn.0254-6450.2018.06.013
- VernacularTitle:金昌队列基线人群脂肪肝与2型糖尿病的关联性研究
- Author:
Y B MA
1
;
N CHENG
2
;
Y B LU
1
;
H Y LI
3
;
J S LI
1
;
J DING
3
;
S ZHENG
1
;
Y L NIU
3
;
H Q PU
3
;
X P SHEN
1
;
H D MU
3
;
X B HU
1
;
D S ZHANG
3
;
Y N BAI
1
Author Information
1. Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China.
2. Institute of Epidemiology and Statistics,Basic Medical College, Lanzhou University, Lanzhou 730000, China.
3. Workers' Hospital of Jinchuan Group Co, Ltd, Jinchang 737100, China.
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Fatty liver;
Interaction;
Jinchang Cohort
- MeSH:
China/epidemiology*;
Cohort Studies;
Diabetes Mellitus, Type 2/ethnology*;
Fatty Liver/ethnology*;
Female;
Humans;
Male;
Non-alcoholic Fatty Liver Disease/epidemiology*;
Prevalence;
Risk Factors
- From:
Chinese Journal of Epidemiology
2018;39(6):760-764
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the association between fatty liver and type 2 diabetes mellitus (T2DM) in the baseline-population of Jinchang cohort study. Methods: Data from all the participants involved in the baseline-population of Jinchang cohort study was used, to compare the risks of T2DM in fatty liver and non fatty liver groups and to explore the interaction between family history or fatty liver of diabetes and the prevalence of T2DM. Results: Among all the 46 861 participants, 10 574 were diagnosed as having fatty liver (22.56%), with the standardized rate as 20.66%. Another 3 818 participants were diagnosed as having T2DM (8.15%) with standardized rate as 6.90%. The prevalence of T2DM increased in parallel with the increase of age (trend χ(2)=2 833.671, trend P<0.001). The prevalence of T2DM in the fatty liver group was significantly higher than that in the non-fatty liver group, both in men or women and in the overall population. Compared with the group of non-fatty liver, the risks of T2DM in fatty liver group were seen 1.78 times higher in males, 2.33 times in women and 2.10 times in the overall population, after adjustment for factors as age, levels of education, smoking, drinking, physical exercise, BMI, family history of diabetes and some metabolic indicators (pressure, TC, TG, uric acid, ALT, AST, gamma-glutamyl transferase). Date from the interaction model showed that fatty liver and family history of diabetes present a positive additive interaction on T2DM (RERI=1.18, 95%CI: 0.59-1.78; AP=0.24, 95%CI: 0.14-0.34; S=1.43, 95%CI: 1.21-1.69). Conclusions: Fatty liver could significantly increase the risk of T2DM and a positive additive interaction was also observed between fatty liver and family history of diabetes on T2DM. It was important to strengthen the prevention program on T2DM, in order to effectively control the development of fatty liver.
