Lead time bias and its control in observational studies for clinical outcomes.
10.3760/cma.j.issn.0254-6450.2018.05.032
- VernacularTitle:临床结局观察性研究中的领先时间偏倚及控制
- Author:
N ZHANG
1
,
2
;
H X LIU
3
;
D M KANG
4
;
N WANG
5
Author Information
1. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
2. Institute for AIDS Control and Prevention, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.
3. Peking University People's Hospital, Beijing 100044, China.
4. Institute for AIDS Control and Prevention, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.
5. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
- Publication Type:Journal Article
- Keywords:
Clinical outcome;
Control;
Highly active antiretroviral therapy;
Lead time bias;
Observational study
- MeSH:
Antiretroviral Therapy, Highly Active;
Bias;
HIV Infections/mortality*;
Humans;
Mass Screening;
Outcome Assessment, Health Care
- From:
Chinese Journal of Epidemiology
2018;39(5):700-703
- CountryChina
- Language:Chinese
-
Abstract:
Lead time bias might exist in observational study for clinical outcomes. This paper summarizes the concept of lead time bias, causes and control of lead time bias by using the studies of influences of screening diagnostic test on cancer patients'survival and highly active antiretroviral therapy on HIV/AIDS patients' survival as examples for the purpose of providing thinking and methods in the control of lead time bias for the accurate evaluation of the effects of interventions, such as test and treatment, on the diseases with multi courses or phases.
