HIV gene subtypes of newly reported HIV/AIDS cases in Dehong Dai and Jingpo autonomous prefecture of Yunnan province, 2016.
10.3760/cma.j.issn.0254-6450.2018.05.027
- VernacularTitle:云南省德宏傣族景颇族自治州2016年新报告艾滋病病毒感染者的基因亚型分析
- Author:
X DUAN
1
,
2
;
K R WANG
3
;
J B WANG
4
;
R H YE
3
;
Y K WANG
3
;
J YANG
3
;
T YANG
3
;
S J ZHOU
4
;
Y C YANG
3
;
S T YAO
3
;
S DUAN
3
;
N HE
4
Author Information
1. Dehong Dai and Jingpo Autonomous Prefectural Center for Disease Control and Prevention, Mangshi 678400, China
2. Department of Epidemiology, School of Public Health, Key Laboratory for Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China.
3. Dehong Dai and Jingpo Autonomous Prefectural Center for Disease Control and Prevention, Mangshi 678400, China.
4. Department of Epidemiology, School of Public Health, Key Laboratory for Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China.
- Publication Type:Journal Article
- Keywords:
Gene subtypes;
HIV;
HIV/AIDS cases
- MeSH:
Base Sequence;
China/epidemiology*;
Ethnicity/genetics*;
Genes, pol;
Genotype;
HIV Infections/genetics*;
HIV-1/genetics*;
Humans;
Male;
Phylogeny;
Polymerase Chain Reaction/methods*;
Serogroup
- From:
Chinese Journal of Epidemiology
2018;39(5):678-681
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore distribution of HIV gene subtypes among newly reported HIV/AIDS cases from China and Myanmar in Dehong Dai and Jingpo prefecture of Yunnan province in 2016. Methods: We conducted DNA extractions from newly reported HIV/AIDS cases in 2016. The gag, env and pol genes were amplified by using reverse transcription-PCR (RT-PCR) and sequenced to identify HIV subtypes. Results: A total of 1 112 newly diagnosed HIV cases were reported in Dehong in 2016, and the HIV subtypes were identified for 860 cases. Subtype C was predominant (33.6%), followed by unique recombinant forms (URFs) (28.4%), CRF01_AE (18.6%) and so on. URFs include four recombination, among which the recombination of CRF01_AE and C subtype were predominant. The HIV subtype distribution was associated with nationality and transmission route in HIV/AIDS cases from Myanmar. Conclusions: The gene subtypes of C, URFs and CRF01_AE were mainly distributed; distribution of URFs remained complex and diverse among newly reported HIV/AIDS cases in Dehong in 2016.
