New psychoactive substances abuse among patients with access to methadone maintenance treatment in Jiangsu province: a case-control study.
10.3760/cma.j.issn.0254-6450.2018.05.016
- Author:
Z CHENG
1
;
G H CHEN
2
;
M M DAI
1
;
W LUO
1
;
P LYU
1
;
X B CAO
1
Author Information
1. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
2. Department of AIDS/STD Prevention and Control, Jiangsu Provincial Center for Diseases Control and Prevention, Nanjing 210009, China.
- Publication Type:Journal Article
- Keywords:
Case-control study;
Methadone maintenance treatment;
New psychoactive substances
- MeSH:
Adult;
Case-Control Studies;
China/epidemiology*;
Drug Users/statistics & numerical data*;
Humans;
Logistic Models;
Male;
Methadone/therapeutic use*;
Methamphetamine;
Middle Aged;
Opiate Substitution Treatment;
Prevalence;
Psychotropic Drugs/adverse effects*;
Substance Abuse Detection/statistics & numerical data*;
Substance Abuse Treatment Centers;
Substance-Related Disorders/epidemiology*;
Surveys and Questionnaires
- From:
Chinese Journal of Epidemiology
2018;39(5):625-630
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the reasons and factors associated with new psychoactive substances abuse among patients with access to methadone maintenance treatment (MMT). Methods: A well-developed questionnaire and urine tests were used to collect information about demographic characteristics, condition of MMT and drug abuse, family and social support of MMT clients. A 1∶1 matched case-control study was conducted, and conditional logistic regression model was used to identify factors associated with new psychoactive substances abuse. Results: A total of 212 (106 pairs) clients receiving MMT were recruited, and most of them were males (78.3%, 166/212), married or cohabitant (48.6%, 103/212) and unemployed (63.2%, 134/212). The average age of the clients was (45.1±7.2) years. The main types of abused new psychoactive substances were benzodiazepine (62.3%, 66/106) and methamphetamine (39.6%, 42/106). The proportion of abusing multi new psychoactive substances was 8.5% (9/106). Results from multivariate conditional logistic regression analysis indicated that using opioid drug during the past 6 months of MMT treatment might increase the risk of abusing new psychoactive substances (OR=3.25, 95%CI: 1.35-7.79), benzodiazepine (OR=3.25, 95%CI: 1.11- 9.47) and methamphetamine (OR=13.31, 95%CI: 1.12-158.01). Moreover, MMT for more than9 years reduced the risk of abuse of new psychoactive substances (OR=0.03, 95%CI: 0.01-0.21), benzodiazepine (OR=0.02, 95%CI: 0.00-0.36) and methamphetamine (OR=0.02, 95%CI: 0.00-0.69). Conclusion: Less new psychoactive substances abuse might be associated with longer duration of MMT treatment. And inappropriate support from family and friends might increase the risk of abusing new psychoactive substances in MMT clients, especially in clients who used opioid.
