Association between total cholesterol and risk of lung cancer incidence in men: a prospective cohort study.
10.3760/cma.j.issn.0254-6450.2018.05.012
- Author:
Z Y LYU
1
;
N LI
1
;
G WANG
2
;
K SU
3
;
F LI
3
;
L W GUO
4
,
5
;
X S FENG
1
;
L P WEI
1
;
H D CHEN
1
;
Y H CHEN
1
;
F W TAN
3
;
W J YANG
1
;
S H CHEN
6
;
J S REN
1
;
J F SHI
1
;
H CUI
1
;
M DAI
1
;
S L WU
6
;
J HE
3
Author Information
1. Office for Cancer Early Diagnosis and Treatment, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
2. Department of Oncology, Kailuan General Hospital, Tangshan 063000, China.
3. Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
4. Office for Cancer Early Diagnosis and Treatment, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
5. Office for Henan Cancer Control and Research, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China.
6. Health Department of Kailuan (group), Kailuan General Hospital, Tangshan 063000, China.
- Publication Type:Journal Article
- Keywords:
Cohort study;
Lung cancer;
Male;
Prospective study;
Total cholesterol
- MeSH:
Adult;
Asian People;
China/epidemiology*;
Cholesterol/blood*;
Cohort Studies;
Humans;
Incidence;
Lipids;
Lung Neoplasms/ethnology*;
Male;
Proportional Hazards Models;
Prospective Studies;
Risk Factors
- From:
Chinese Journal of Epidemiology
2018;39(5):604-608
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the association and intensity of baseline TC level with the incidence of lung cancer in men in China. Methods: Since May 2006, all the male workers, including the employees and the retirees in Kailuan Group were recruited in the Kailuan male dynamic cohort study. Information about demographics, medical history, anthropometry and TC level were collected at the baseline interview, as well as the information of newly-diagnosed lung cancer cases during the follow-up period. According to guidelines for blood lipids in Chinese adults and the distribution in the population, TC level was classified into five groups as followed: <160, 160-, 180-, 200- and ≥240 mg/dl, with the second quintile group (160- mg/dl) serving as the referent category. Cox proportional hazards regression model and restricted cubic spline (RCS) model were used to evaluate the association and the nonlinear association between baseline TC level and the risk of lung cancer in the men. Results: By December 31, 2014, for the 109 884 men, a follow up of 763 819.25 person-years was made with a median follow-up period of 7.88 years. During the follow up, 808 lung cancer cases were identified. After adjustment for age, education level, income level, smoking status, alcohol consumption level, history of dust exposure, FPG level and BMI, HR (95%CI) of lung cancer for men with lower TC level (<160 mg/dl) and higher TC level (≥240 mg/dl) were 1.34 (1.04- 1.72) and 1.45 (1.09-1.92), respectively, compared with men with normal TC level (160- mg/dl). The results didn't change significantly after exclusion of newly diagnosed cancer cases within 2 years of follow up and subjects with the history of hyperlipidemia. Conclusion: Our results showed that TC might be associated with higher risk of lung cancer. Men with lower TC level or higher TC level had higher risk for lung cancer. Keep moderate TC level might be one of the effective precaution for the prevention of lung cancer.
