Risk on bias assessment: (6) A Revised Tool for the Quality Assessment on Diagnostic Accuracy Studies (QUADAS-2).
10.3760/cma.j.issn.0254-6450.2018.04.028
- Author:
Y J QU
1
;
Z R YANG
2
;
F SUN
3
;
S Y ZHAN
3
Author Information
1. Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
2. Primary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridgeshire CB1 8RN, UK.
3. Department of Epidemiology and Biostatistics, School of Public Health, Center of Evidence-based Medicine and Clinical Research, Peking University, Beijing 100191, China.
- Publication Type:Journal Article
- Keywords:
Diagnostic accuracy studies;
Risk of bias;
Systematic review;
Tool for assessment
- MeSH:
Bias;
Diagnostic Tests, Routine/standards*;
Humans;
Quality Assurance, Health Care;
Research Report;
Risk
- From:
Chinese Journal of Epidemiology
2018;39(4):524-531
- CountryChina
- Language:Chinese
-
Abstract:
This paper introduced the Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2), including the development and comparison with the original QUADAS, and illustrated the application of QUADAS-2 in a published paper related to the study on diagnostic accuracy which was included in systematic review and Meta-analysis. QUADAS-2 presented considerable improvement over the original tool. Confused items that included in QUADAS had disappeared and the quality assessment of the original study replaced by the rating of risk on bias and applicability. This was implemented through the description on the four main domains with minimal overlapping and answering the signal questions in each domain. The risk of bias and applicability with 'high','low' or 'unclear' was in line with the risk of bias assessment of intervention studies in Cochrane, so to replace the total score of quality assessment in QUADAS. Meanwhile, QUADAS-2 was also applicable to assess the diagnostic accuracy studies in which follow-up without prognosis was involved in golden standard. It was useful to assess the overall methodological quality of the study despite more time consuming than the original QUADAS. However, QUADAS-2 needs to be modified to apply in comparative studies on diagnostic accuracy and we hope the users would follow the updates and give their feedbacks on line.
