Association between DRD2 gene polymorphisms and the dosage used on methadone maintenance treatment program.
10.3760/cma.j.issn.0254-6450.2018.02.011
- VernacularTitle:DRD2基因多态性与美沙酮维持治疗剂量的关联性研究
- Author:
L X DUAN
1
;
X L LI
1
;
P W HU
2
;
R LUO
1
;
X LUO
1
;
Y Y CHEN
1
Author Information
1. Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China.
2. Department of Scientific Research, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- Keywords:
DRD2 gene;
Methadone maintenance treatment;
Single nucleotide polymorphism;
Treatment dose
- MeSH:
Alleles;
Case-Control Studies;
Drug Dosage Calculations;
Genotype;
Humans;
Methadone/therapeutic use*;
Opiate Substitution Treatment;
Opioid-Related Disorders/rehabilitation*;
Polymorphism, Single Nucleotide/genetics*;
Receptors, Dopamine D2/genetics*
- From:
Chinese Journal of Epidemiology
2018;39(2):194-198
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the association between three single nucleotide polymorphism (SNP) genes DRD2 (rs1800497, rs6275, and rs1799978) and the dosage used on methadone maintenance treatment (MMT). Methods: From the methadone maintenance treatment centers, 257 MMT patients were recruited to participate in a case-control study and divided into two groups-control groups under low dosage (n=89) and case (n=168) group with high dosage. Quanto software was used to estimate the sample size as 180. Information related to social-demographic status, history on drug use and medication were collected. And DRD2 SNPs were genotyped to explore the relationship between polymorphism of DRD2 gene and the dosage of methadone maintenance treatment. Results: Distributions of DRD2 rs6275 between different groups were significantly different. Patients carrying TC genotype needed lower dose of methadone when compared to the patients that carrying CC genotype counterparts (OR=0.338, 95% CI: 0.115-0.986). Patients that carrying C allele at rs6275 needed lower methadone dose than those that carrying genotype TT (OR=0.352, 95% CI: 0.127-0.975). Distributions of genotypes, alles in the other two SNPs (rs1800497, rs1799978) were not significantly different between groups under different dosages. Conclusion: DRD2 rs6275 was associated with dosage of methadone used for the MMT patients. However, no significant associations were found between rs1800497, rs1799978 and the dosage of methadone.
