Exposure to bisphenol A during maternal pregnancy and the emotional and behavioral impact on their preschool children.
10.3760/cma.j.issn.0254-6450.2018.02.010
- VernacularTitle:孕期双酚A暴露对学龄前儿童情绪和行为问题的影响
- Author:
X CHEN
1
;
H H BAO
1
;
W K WU
1
;
S Q YAN
2
;
J SHENG
3
;
Y Y XU
4
,
5
;
C L GU
2
;
K HUANG
4
,
5
;
H CAO
2
;
P Y SU
4
,
5
;
F B TAO
4
,
5
;
J H HAO
4
,
5
Author Information
1. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China.
2. Ma'anshan Maternal and Child Health Center, Ma'anshan 243000, China.
3. Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China.
4. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China
5. Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China.
- Publication Type:Journal Article
- Keywords:
Bisphenol A;
Child behavior;
Pregnancy
- MeSH:
Benzhydryl Compounds/toxicity*;
Child Behavior Disorders/etiology*;
Child, Preschool;
China/epidemiology*;
Cohort Studies;
Emotions/physiology*;
Environmental Exposure;
Environmental Pollutants;
Female;
Gas Chromatography-Mass Spectrometry;
Humans;
Male;
Maternal Exposure;
Mothers;
Phenols/toxicity*;
Pregnancy;
Prenatal Exposure Delayed Effects;
Prevalence;
Risk Factors;
Surveys and Questionnaires;
Tandem Mass Spectrometry
- From:
Chinese Journal of Epidemiology
2018;39(2):188-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the long-term effects of maternal pregnancy bisphenol A (BPA) exposure on emotional and behavioral problems appeared in their preschool children. Methods: The study sample was a subset of the China-Anhui Birth Cohort Study (C-ABCS). A unified questionnaire was used to collect basic information on both pregnant women and their children. Free BPA concentration in maternal serum was determined by high-performance liquid chromatographytandem mass spectrometry (HPLC-MS/MS). The parent-report version of the Strengths and Difficulties Questionnaire (SDQ) was used to estimate the emotional and behavioral problems in preschool children. A total of 1 713 pairs of mothers and children were included in this study. Association between BPA exposure during pregnancy and the emotional and behavioral problems in preschool children was evaluated with multinomial logistic regression model. Results: Prevalence rates in 1 713 preschool children appeared as: 6.48% of emotional problems, 8.11% for conduct problems, 8.35% for hyperactivity/inattention, 2.86% for peer problems, 11.38% for prosocial behaviors and 7.94% for total difficulties. Subjects were divided according to the degrees of exposure and the results showed as: low exposure group (≤0.120 ng/ml), medium exposure group (0.120OR=1.876, 95% CI: 1.161-3.029), more obvious in boys (OR=2.291, 95%CI: 1.126-4.661). Conclusion: Maternal exposure to high level of BPA during pregnancy might increase the detrimental effects of abnormal conducts in their preschool children, more obviously seen in boys.
