The Effect of Intracameral Triamcinolone Acetonide Injection on the Cornea in Rabbits.
10.3341/jkos.2008.49.4.634
- Author:
Joo Youn PARK
1
;
Hoon Dong KIM
;
Kyung Seek CHOI
Author Information
1. Department of Ophthalmology, Soonchunhyang University College of Medicine, Seoul, Korea. ckseek@naver.com
- Publication Type:Original Article
- Keywords:
Cornea;
Intracameral triamcinolone acetonide injection
- MeSH:
Anterior Chamber;
Cell Count;
Cornea;
Endothelial Cells;
Eye;
In Situ Nick-End Labeling;
Intraocular Pressure;
Rabbits;
Triamcinolone;
Triamcinolone Acetonide
- From:Journal of the Korean Ophthalmological Society
2008;49(4):634-640
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the safety and effects of intracameral triamcinolone acetonide injection in rabbit corneas. METHODS: Triamcinolone acetonide in the amounts of 0.5, 1, and 2 mg was injected into the anterior chamber of rabbit eyes, and intraocular pressure, corneal thickness, and endothelial cell counts were evaluated on days 1, 3, 7, 14, and 28. Twenty-eight days after triamcinolone acetonide injection, the eyes were enucleated and examined after TUNEL staining. RESULTS: No statistically significant differences were found among control, 0.5, and 1 mg triamcinolone-injected eyes in central corneal thickness, endothelial cell density, pleomorphism, and polymegathism. There was no difference between 2 mg triamcinolone-injected eyes and control eyes for corneal thickness and cell density, but there were statistically significant differences between these two groups for pleomorphism (p<0.05) and polymegathism (p<0.05). CONCLUSIONS: The results of this study suggested that intracameral injections of 0.5~1 mg of triamcinolone acetonide are beneficial and cause no toxic effects on corneas.
