Circulation and etiological characterization of Salmonella enterica serotype in human in Guangdong province, 2007-2016.
10.3760/cma.j.issn.0254-6450.2018.01.013
- Author:
B X KE
1
;
H H ZENG
2
;
D M HE
1
;
H L TAN
1
;
B S LI
1
;
Y H LIANG
1
;
C W KE
1
Author Information
1. Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
2. Guangdong Provincial Institute of Biological Products and Material Medicine, Guangzhou 510440, China.
- Publication Type:Journal Article
- Keywords:
Drug resistance;
Molecular characteristics;
Salmonella 1, 4, [5], 12: i: -
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Anti-Bacterial Agents/pharmacology*;
Child;
Child, Preschool;
China/epidemiology*;
Diarrhea/microbiology*;
Drug Resistance, Bacterial;
Electrophoresis, Gel, Pulsed-Field;
Female;
Humans;
Infant;
Male;
Microbial Sensitivity Tests;
Middle Aged;
Salmonella Infections/prevention & control*;
Salmonella enterica/isolation & purification*;
Salmonella typhimurium;
Serogroup;
Serotyping;
Young Adult
- From:Chinese Journal of Epidemiology
2018;39(1):63-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the circulation, drug resistance and molecular characteristics of Salmonella1, 4, [5], 12: i:- in human in Guangdong province. Methods:Salmonella1, 4, [5], 12: i:- isolated from diarrhea patients in Guangdong during 2007-2016 were detected for drug resistance, genes and PFGE characteristics. Results: A total of 2 960 strains Salmonella1, 4, [5], 12: i: - were isolated from human diarrhea cases during this period. The positive rates of the isolation increased year by year. The male to female ratio of the infection cases was 1.58∶1, and the infection mainly occurred in infants and young children. Except imipenem, Salmonella1, 4, [5], 12: i: - was resistant to other 17 antibiotics to some extent. The drug resistant rates to ceftazidime, cefotaxime and ciprofloxacin increased from 2011 to 2016. Multi-drug resistance was serious, for example, the multi-drug resistant strains with ASSuT accounted for 70.62% (435/616) and the multi-drug resistant strains with ACSuGSTTm accounted for 27.11% (167/616). The lack of fljA, fljB and hin genes, as well as the retaining of iroB, STM2740, STM2757 genes, resulted in the unable expression of FljBenx gene with 8 different defection profiles. There were 934 different PFGE patterns observed in 2 347 strains, which displayed a relatively large fingerprint polymorphism. The major PFGE pattern was JPXX01. GD0226, which was found in 97 strains, accounting for 4.13% (97/2 347). The PFGE patterns in 168 Salmonella1, 4, [5], 12: i: - strains were consistent with that of Salmonella typhimurium. Conclusions:Salmonella1,4,[5], 12: i: - strains has become the major serotype of Salmonella that cause diarrhea in human in Guangdong. The multi-drug resistance of Salmonella1,4, [5], 12: i: - was serious, and since the defection of fljA, fljB and hin genes, the expression of FljBenx protein failed. The PFGE results were diverse, which displayed polymorphism in inheritance.
