Relationship between exposure to air pollutants during pre-pregnancy or early pregnancy and birth defects in Xi'an, 2013-2015: a case crossover study
10.3760/cma.j.issn.0254-6450.2017.12.019
- VernacularTitle:西安市2013-2015年产妇孕前期和孕早期空气污染物暴露对出生缺陷影响的病例交叉研究
- Author:
Qi ZHANG
1
;
Xiaomei XIANG
;
Hui SONG
;
Min DONG
;
Shuiping ZHANG
;
Baibing MI
;
Lingling WANG
;
Li ZHANG
;
Hong YAN
;
Shaonong DANG
Author Information
1. 710061,西安交通大学医学部公共卫生学院流行病与卫生统计教研室
- Keywords:
Air pollutants;
Birth defects;
Case-crossover study
- From:
Chinese Journal of Epidemiology
2017;38(12):1677-1682
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the levels of exposure to traffic-related air pollutants including nitrogen dioxide (NO2),PM10 and PM2.5,and the relationship between the exposure to air pollutants during pre-pregnancy or early pregnancy and birth defects.Methods Data on air pollution and birth defects from 2013 to 2015 was collected.A case-crossover design was employed to analyze the exposure-response relationship between traffic-related air pollutants and birth defects.Results A total of 4 235 pregnant women were studied.During the study period,the daily average concentrations of ambient NO2,PM10 and PM25 appeared as 60.83 μg/m3,104.94 μg/m3 and 103.88 μ.tg/m3,respectively,with the concentration of PM2.5 larger than the 2nd version of Standard National Ambient Air Quality Standard.In addition,there were strong correlations seen between each of the pollutants (P＜0.01).After adjustment for the influence of meteorological factors,it was found that the exposure to high level of NO2 and PM10 during pre-pregnancy or early pregnancy increased the risk on birth defects (P＜0.05).Conclusion Levels of exposure to adverse environmental factors during pre-pregnancy or early pregnancy could increase the risk of birth defects,suggesting that in these sensitive periods,women should try to avoid being exposed to high concentration of traffic-related air pollutants as NO2,PM10 etc.in order to reduce the risk of birth defects.
