Outcomes of pregnancy among women with alpha-thalassemia minor: A retrospective study of Pingguo county in Guangxi Zhuang Autonomous Region
10.3760/cma.j.issn.0254-6450.2017.12.007
- VernacularTitle:广西壮族自治区平果县孕妇妊娠合并轻型α-地中海贫血对妊娠结局的回顾性分析
- Author:
Ting PANG
1
;
Xuefeng GUO
;
Yuehong ZHOU
;
Xiaoqiang QIU
;
Shu LI
;
Zerui LIANG
;
Xiaoling QIN
;
Kehua LI
;
Xiaoyun ZENG
Author Information
1. 广西医科大学公共卫生学院流行病与卫生统计学教研室
- Keywords:
α-thalassemia;
Pregnancy outcomes;
Birth weight
- From:
Chinese Journal of Epidemiology
2017;38(12):1620-1623
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the value of α-thalassemia minor and the outcomes in pregnant women.Methods A total of 445 pregnant women with α-thalassemia minor were selected as thalassemia group in the Pingguo County Maternal and Child Health Hospital of Guangxi from January 2011 to December 2015,with ratio of 1 ∶ 4 healthy pregnant women was randomly recruited as non-thalassemia group.Clinical characteristics and pregnancy outcomes of the two groups were retrospectively analyzed using methods including t test,x2 test,and logistic regression model and ROC curve.Results There were no significant differences noticed in factors as age,BMI,gestational age and educational level of the two groups.Hemoglobin of the thalassemia group was significantly lower than that of the non-thalassemia group (P＜0.001).Differences on parity,ethnicities or occupation were statistically significant.Results from univariate analysis showed that the proportions of low birth weight,small for date infant and 1 min Apgar score ＜7 were higher in the thalassemia group,but the ratio of adverse pregnancy outcomes was comparable on parameters as preterm birth,stillbirth,macrosomia.Findings from the unconditional logistic regression showed that pregnancy complicated with α-thalassemia minor appeared a risk for both newboms with low birth weight (aOR=2.29,95％CI:1.32-3.95) and small for date infant (aOR=2.11,95％ CI:1.16-3.84).The ROC curve showed that α-thalassemia minor combined with multiple indicators presented a certain predictive value on neonatal birth weight.Conclusion Pregnancy complicated with α-thalassemia minor was likely to increase the risk of birth weight loss in newborns,suggesting that prenatal care for pregnant women with thalassemia be strengthened,in order to reduce the incidence of adverse pregnancy outcomes.
