Multivariate ordinal logistic regression analysis on the association between consumption of fried food and both esophageal cancer and precancerous lesions
10.3760/cma.j.issn.0254-6450.2017.12.006
- VernacularTitle:油炸食品与食管癌及癌前病变关系的多元有序logistic回归分析
- Author:
Lanwei GUO
1
,
2
;
Shuzheng LIU
;
Meng ZHANG
;
Qiong CHEN
;
Shaokai ZHANG
;
Xibin SUN
Author Information
1. 450008 郑州大学附属肿瘤医院/河南省肿瘤医院河南省肿瘤防治研究办公室
2. 100021 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院城市癌症早诊早治项目办公室
- Keywords:
Fried food;
Esophageal cancer;
Precancerous lesions
- From:
Chinese Journal of Epidemiology
2017;38(12):1616-1619
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of fried food intake on the pathogenesis of esophageal cancer and precancerous lesions.Methods From 2005 to 2013,all the residents aged 40-69 years from 11 counties (cities) where cancer screening of upper gastrointestinal cancer had been conducted in rural areas of Henan province,were recruited as the subjects of study.Information on demography and lifestyle was collected.The residents under study were screened with iodine staining endoscopic examination and biopsy samples were diagnosed pathologically,under standardized criteria.Subjects with high risk were divided into the groups based on their different pathological degrees.Multivariate ordinal logistic regression analysis was used to analyze the relationship between the frequency of fried food intake and esophageal cancer and precancerous lesions.Results A total number of 8 792 cases with normal esophagus,3 680 with mild hyperplasia,972 with moderate hyperplasia,413 with severe hyperplasia carcinoma in situ,and 336 cases of esophageal cancer were recruited.Results from multivariate logistic regression analysis showed that,when compared with those who did not eat fried food,the intake of fried food (＜2 times/week:OR=1.60,95％C1:1.40-1.83;≥2 times/week:OR=2.58,95％ CI:1.98-3.37) appeared a risk factor for both esophageal cancer or precancerous lesions after adjustment for age,sex,marital status,educational level,body mass index,smoking and alcohol intake.Conclusion The intake of fried food appeared a risk factor for both esophageal cancer and precancerous lesions.
