Molecular epidemiology and transmission of HIV-1 infection in Zhejiang province, 2015
10.3760/cma.j.issn.0254-6450.2017.11.023
- VernacularTitle:浙江省2015年HIV分子亚型特征及其传播关系研究
- Author:
Jiezhe YANG
1
;
Wanjun CHEN
;
Wenjun ZHANG
;
Lin HE
;
Jiafeng ZHANG
;
Xiaohong PAN
Author Information
1. 浙江省疾病预防控制中心性病艾滋病预防控制所
- Keywords:
Human immunodeficiency virus;
Subtype;
Transmission cluster
- From:
Chinese Journal of Epidemiology
2017;38(11):1551-1556
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the distribution of HIV-1 subtype diversity and its transmission characteristics in Zhejiang province. Methods A total of 302 newly diagnosed HIV-1 positive patients were selected through stratified random sampling in Zhejiang in 2015. HIV-1 pol genes were sequenced successfully with reverse transcription PCR/nested PCR and phylogenetic analysis was conducted for 276 patients. Then a molecular epidemiologic study was performed combined with field epidemiological investigation. Results Of 276 sequence samples analyzed, 122 CRF07_BC strains (44.2%), 103 CRF01_AE strains (37.3%), 17 CRF08_BC strains (6.1%), 9 B strains (3.2%), 6 CRF55_01B strains (2.2%), 5 C strains (1.8%), 1 CRF59_01B strain (0.4%), 1 CRF67_01B strain (0.4%), 1 A1 strain (0.4%), and 11 URFs strains (4.0%) were identified. Phylogenetic analysis revealed 16 clusters with only 15.1% (34/225) sequences involved among CRF07_BC and CRF01_AE strains. The clustered cases in MSM were higher than that in populations with other transmission routes. And clusters existed between the populations with different transmission routes. Conclusion The major strains of HIV-1 in Zhejiang are CRF07_BC and CRF01_AE. The HIV subtypes showed more complexity in Zhejiang. It is necessary to strengthen the surveillance for HIV subtypes, carry out classified management and conduct effective prevention and control in the population at high risk.
