Association and effects of gene-gene interactions between peroxisome proliferator-activated receptor and pulse pressure
10.3760/cma.j.issn.0254-6450.2017.10.022
- VernacularTitle:过氧化物酶体增殖物激活受体多态性及基因-基因交互作用对脉压的影响
- Author:
Hui ZHOU
1
;
Yi DING
;
Ming WU
;
Wei FAN
;
Hao YU
;
Zhengyuan ZHOU
;
Shujun GU
;
Lijun ZHANG
;
Chen DONG
;
Zhirong GUO
Author Information
1. 215021,苏州市工业园区疾病防治中心
- Keywords:
Pulse pressure;
Peroxisome proliferator-activated receptors;
Generalized multifactor dimensionality reduction;
Interaction
- From:
Chinese Journal of Epidemiology
2017;38(10):1404-1409
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between ten single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptors and pulse pressure (PP) as well as the relationships between gene-gene interaction between PPARα/δ/γ genes and PP.Methods A total of 820 subjects,with 550 females and 270 males,were recruited from a cohort study of “Prevention of Metabolic Syndrome and Multi-metabolic Disorders in Jiangsu Province of China Study (PMMJS)”.Ten SNPs of PPARα/δ/γ genes were selected.GMDR software (version 1.0.1) was used to evaluate the gene-gene interactions among PPARs SNPs associated with PP.Results The mean levels of PP in people with mutant genotype of rs1805192 in PPARγ genes (PA+AA) showed a significant increase by 1.341 mmHg (95％CI:0.431-2.252 mmHg) when compared to the persons with wild genotype (PP).In the subgroup of subjects with more than 30 mmHg levels of PP,a six-locus model comprised rs135539 of PPARα,rs2016520 of PPARδ,rs10865710,rs1805192,rs709158 and rs3856806 of PPARγshowed a highest level of prediction accuracy (0.577) and displayed a better cross-validation consistency (10/10).In the subgroup of subjects with less than 40 mmHg levels of PP,a two-locus model was statistically associated with PP with 0.628 of prediction accuracy and 10/10 of cross-validation consistency.Conclusion PPARγrs1805192 was associated with the occurrence of PP.Gene-gene interactions among rs135539 of PPARα,rs2016520 of PPARδ,rs10865710,rs1805192,rs709158 and rs3856806 of PPARγ were all significantly related to PP.
