A 22-year-follow-up cohort study on primary liver cancer in Haimen city of Jiangsu province
10.3760/cma.j.issn.0254-6450.2017.10.016
- VernacularTitle:江苏省海门市原发性肝癌队列随访结果分析
- Author:
Peixin HUANG
1
;
Na WANG
;
Junhua QIAN
;
Feng JIANG
;
Yanlei YANG
;
Wenyao LIN
;
Qi ZHAO
;
Genming ZHAO
;
Qingwu JIANG
Author Information
1. 226121,海门市疾病预防控制中心慢病科
- Keywords:
Primary liver cancer;
Risk factors;
Surface antigen of hepatitis B virus;
Cohort study
- From:
Chinese Journal of Epidemiology
2017;38(10):1376-1379
- CountryChina
- Language:Chinese
-
Abstract:
Objective A prospective cohort study was carried out to assess the mortality and potential risk factors for primary liver cancer (PLC) in Haimen city of Jiangsu province.Methods The cohort involved 89 789 adult residents aged 25-69 years.Upon the entry of this project,each subject was asked to complete a questionnaire and to provide a blood sample of 10 ml.Surface antigen of hepatitis B virus (HBsAg) was tested by radioimmunoassay.All the subjects were followed-up every year for vital statistics and death certificate information until 2014.Cox proportional hazard model was used to estimate the hazard ratio (HR) and 95％ confidence interval (95％ CI) for PLC mortality associated with HBsAg status and other risk factors.Results During the 1 299 611 person-years of follow-up,a total of 2 583 PLC cases were identified,including 2 149 men and 434 women.Mortality of the PLC for men and women were 247.80/100 000 person-years and 100.38/100000 person-years,respectively.Among those who died of PLC,73.87％ had been tested HBsAg positive.HBV infection seemed the predominant risk factor for PLC and the HRs were 15.97 for men (95％CI:14.29-17.85) and 21.63 for women (95％CI:16.16-28.96) respectively.Ageing,cigarette smoking,previous history of hepatitis,and family history of HCC were factors associated with the increased risk for PLC.Conclusion People living in Haimen city had a high risk on PLC.HBV infection appeared the most important risk factor for HCC mortality in this area.
