Expression of Cancer-Testis Genes in Brain Tumors.
10.3340/jkns.2008.43.4.190
- Author:
Myoung Hee LEE
1
;
Eun Ik SON
;
Ealmaan KIM
;
In Soo KIM
;
Man Bin YIM
;
Sang Pyo KIM
Author Information
1. Department of Neurosurgery, Keimyung University School of Medicine, Daegu, Korea. drson@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Cancer-testis gene;
Brain tumor;
MAGE-E1;
SOX-6;
SCP-1;
SSX-2
- MeSH:
Acetaminophen;
Astrocytoma;
Brain;
Brain Neoplasms;
Central Nervous System Neoplasms;
Glioblastoma;
Humans;
Immunotherapy;
Meningioma;
Neurilemmoma;
Polymerase Chain Reaction;
Saccharin
- From:Journal of Korean Neurosurgical Society
2008;43(4):190-193
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Cancer-testis (CT) genes are considered promising candidates for immunotherapeutic approaches. The aim of this study was to investigate which CT genes should be targeted in immunotherapy for brain tumors. METHODS: We investigated the expression of 6 CT genes (MAGE-E1, SOX-6, SCP-1, SSX-2, SSX-4, and HOMTES-85) using reverse-transcription polymerase chain reaction in 26 meningiomas and 32 other various brain tumor specimens, obtained from the patients during tumor surgery from 2000 to 2005. RESULTS: The most frequently expressed CT genes of meningiomas were MAGE-E1, which were found in 22/26 (85%) meningioma samples, followed by SOX-6 (9/26 or 35%). Glioblastomas were most frequently expressed SOX-6 (6/7 or 86%), MAGE-E1 (5/7 or 71%), followed by SSX-2 (2/7 or 29%) and SCP-1 (1/7 or 14%). However, 4 astrocytomas, 3 anaplastic astrocytomas, and 3 oligodendroglial tumors only expressed MAGE-E1 and SOX-6. Schwannomas also expressed SOX-6 (5/6 or 83%), MAGE-E1 (4/6 or 67%), and SCP-1 (2/6 or 33%). CONCLUSION: The data presented here suggest that MAGE-E1 and SOX-6 genes are expressed in a high percentage of human central nervous system tumors, which implies the CT genes could be the potential targets of immunotherapy for human central nervous system tumors.
