Prenatal exposure to ambient air pollution and congenital heart disease: a Meta-analysis
10.3760/cma.j.issn.0254-6450.2017.08.025
- VernacularTitle:孕期环境空气污染物暴露和先天性心脏病关系的Meta分析
- Author:
Shanshan LI
1
;
Ruo ZHANG
;
Xin LAN
;
Pengfei QU
;
Shaonong DANG
;
Fangyao CHEN
;
Hong YAN
Author Information
1. 710061,西安交通大学医学部公共卫生学院流行病与卫生统计学系
- Keywords:
Air pollutants;
Congenital heart diseases;
Fertile period
- From:
Chinese Journal of Epidemiology
2017;38(8):1121-1126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between exposure to ambient air pollution during pregnancy and congenital heart disease so as to provide evidence for primary prevention of congenital heart disease.Methods Epidemiologic studies on ambient air pollution and congenital heart diseases were reviewed.Summary risk estimates were calculated at high versus low exposure levels and risk per-unit-increase in continuous pollutant concentration.Meta-analysis was conducted with Stata 12.0 software.Results A total of 20 articles in English were qualified for inclusion.Results from Meta-analysis showed that CO exposures were related to the increase on the risk of tetralogy of fallot (high versus low exposure level OR=1.22,95％CI:1.03-1.44),while the exposures to NO2 were related to the increase on risk of coarctation of aorta (per 10 mm3/m3 OR=1.01,95％CI:1.01-1.20).Exposures to O3 were related to the increase on risk of atrial septal defect (per 10 mm3/m3 OR=1.14,95％CI:1.03-1.26),and PM10 exposures were related to the increase on risk of atrial septal defect (per 10 μg/m3 OR=1.10,95％CI:1.03-1.19).In addition,there were inverse associations between CO and atrial septal defect and between PM10 and ventricular septal defect.Conclusion Exposures to CO,NO2,O3,PM10 during pregnancy seemed to be associated with congenital heart diseases.
