Acceptability of pre-exposure HIV prophylaxis clinical trial among MSM in Shenyang city
10.3760/cma.j.issn.0254-6450.2017.08.017
- VernacularTitle:沈阳市MSM参加HIV暴露前预防性用药临床试验的接受意愿调查
- Author:
Xiang MAO
1
;
Huan YU
;
Qinghai HU
;
Jing ZHANG
;
Zhenxing CHU
;
Yanan WANG
;
Wenqing GENG
;
Yongjun JIANG
;
Junjie XU
Author Information
1. 中国医科大学附属第一医院检验科国家卫生和计划生育委员会艾滋病免疫学重点实验室
- Keywords:
Men who have sex with men;
Pre-exposure prophylaxis;
Acceptability;
On-demand basis
- From:
Chinese Journal of Epidemiology
2017;38(8):1083-1087
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the acceptability and related factors of an "on-demand"pre-exposure prophylaxis (PrEP) to prevent HIV transmission among MSM in Shenyang.Methods MSM recruited by non-probability sampling method and questionnaire survey conducted by investigators to collect information on social and behavioral characteristics,awareness of PrEP,Truvada and the acceptability of two different PrEP-based trials.Multivariate logistic regression was employed for statistical analysis.Results Among the 292 respondents,34.2％ had heard of PrEP and 58.2％ (170/292) reported were interested in participating a PrEP trial-"on-demand" use or 48.3％ (141/292) interested on "daily" use (x2=5.785,P=0.02).Factors independently associated with those "on-demand" would include:having more than 2 male sexual partners during the past 6 month (aOR=1.7,95％CI:1.1-2.7),concerning on the positive effect of PrEP (vs.side effects) (aOR=6.4,95％CI:2.2-18.9),having an HIV-infected sexual partners (aOR=8.1,95％ CI:1.0-63.3) and self-reported high risk for HIV (aOR=2.6,95％CI:1.2-6.0).The last two factors were only associated with the "on-demand" group.Conclusions "On-demand" PrEP (as opposed to daily) seemed a more feasible prevention strategy on HIV and particularly in those having high risk behavior of HIV.For those who could not follow the daily medication or having HIV risk perception,"On-demand" basis PrEP trial should be recommended for them to follow.
