Less common variants association study and statistical analysis
10.3760/cma.j.issn.0254-6450.2017.07.026
- VernacularTitle:低频变异关联研究与统计检验
- Author:
Xin LIAO
1
;
Jing DENG
;
Jiayu XUN
;
Junxia YAN
Author Information
1. 中南大学湘雅公共卫生学院流行病与卫生统计学系
- Keywords:
Less common variants;
Association study;
Statistical test
- From:
Chinese Journal of Epidemiology
2017;38(7):977-982
- CountryChina
- Language:Chinese
-
Abstract:
In the past decade,based on the “common disease-common variant” hypothesis,genomewide association studies (GWAS) have been extensively used to dissect the genetic components of complex diseases and quantitative traits.However,the identified disease-associated common variants by GWASs can only explain small part of the corresponding disease heritability.“Common disease-rare variant” hypothesis has been proposed to explore the missed heritability.With the development of the next generation sequencing technology,various association studies of less common variants are ongoing.This paper provides an overview of the study designs and statistical tests of these variants.
