Influencing factors for non/low-response to hepatitis-B vaccine in infants of HBsAg positive mothers
10.3760/cma.j.issn.0254-6450.2017.07.013
- VernacularTitle:HBsAg阳性母亲所生婴儿乙型肝炎疫苗无/弱应答的影响因素研究
- Author:
Bin WANG
1
;
Xixi XU
;
Haixiu WEN
;
Haiyun HAO
;
Zhiqing YANG
;
Xiaohong SHI
;
Zhendong FU
;
Xuefei WANG
;
Fang ZHANG
;
Bo WANG
;
Suping WANG
Author Information
1. 山西医科大学公共卫生学院流行病学教研室
- Keywords:
Hepatitis B vaccines;
Infant;
Non/low response
- From:
Chinese Journal of Epidemiology
2017;38(7):911-915
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influencing factors for non/low-response to hepatitis B vaccine in infants of HBsAg-positive mothers.Methods A total of 286 HBsAg-positive pregnant women and their infants were recruited from the Third People's Hospital of Taiyuan during July 2011 to January 2013.The infants were immunized with hepatitis B vaccine according to the 0-1-6 month vaccination schedule and followed up for 12 months.The serum HBV DNA level of mothers,neonates and infants were detected by electro chemilum inescence immunoassay kits and fluorescene quantiative polymerase chain rection.Results Among 286 infants,the rate of non/low-response to hepatitis B vaccine was 18.53％ (53/286).Non-conditional logistic regression analysis indicated that the mother's HBV DNA level ≥ 1 × 107 copies/ml (0R=2.592,95％CI:1.121-5.996) and natural birth (OR=1.932,95％CI:1.021-3.654) were the risk factors for non/low-response to hepatitis B vaccine,the risks were 2.592 times and 1.932 times higher compared with the infants whose mothers were HBV DNA negative and the infants whose mothers had cesarean delivery.There was no multiplicative or additive interaction between high HBV DNA load and natural birth (OR=1.055,95％CI:0.209-5.321),(RERI=1.617,95％CI:-4.038-7.272;AP=0.364,95％CI:-).527-1.225;SI=1.195,95％CI:0.270-13.135).After stratified analysis of mother's HBV DNA level,delivery mode of mothers was not associated with non/low-response of their infants.Conclusion The mother's load of HBV DNA ≥ 1 × 107 copies/ml might be the factor for non/low-response to hepatitis B vaccine in infants of HBsAg positive mothers.
