Correlation between insufficient methadone dosage and morphine positive urine on drop out of treatment in patients with access to methadone maintenance treatment
10.3760/cma.j.issn.0254-6450.2017.05.018
- VernacularTitle:美沙酮维持治疗者服药剂量不足及吗啡尿检阳性与脱失的关系
- Author:
Tian YAO
1
;
Dan FENG
;
Minghu PAN
;
Yanpeng CHENG
;
Chunxia LI
;
Jun WANG
;
Yongliang FENG
;
Jing SHI
;
Tong SU
;
Qing CHEN
;
Shan SHI
;
Suping WANG
Author Information
1. 山西医科大学流行病学教研室
- Keywords:
Methadone maintenance treatment;
Drop out;
Morphine urine;
Dosage;
Interaction
- From:
Chinese Journal of Epidemiology
2017;38(5):646-650
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the incidence of drop out of treatment in patients with access to methadone maintenance treatment and explore the correlation and interaction between insufficient methadone dosage and morphine positive urine on the drop out in Guangxi Zhuang Autonomous Region.Methods Face to face interview was conducted in 1 031 patients at 3 methadone maintenance treatment clinics in Guangxi.Results The study included 1 031 participants,40.6％ of them (419/1 031) had stopped treatment.The drop out rates in urine morphine positive group and methadone dosage ＜ 100 mg/d group were 57.6％ (99/172) and 37.4％ (347/929) respectively,higher than those in urine morphine negative group and methadone dosage ≥ 100 mg/d group (42.3％,363/ 859,and 26.5％,27/102).Orderly logistic regression analysis results showed that after adjusted factors,such as gender,age,marital status,ethnic group,patients who received a dosage less than 1 00 mg/day (OR=3.05,95％CI:1.84-5.06) and had morphine positive urine (OR=2.25,95％CI:1.59-3.19) were more likely to drop out of the treatment.Interaction analysis showed that dosage less than 100 mg/d and morphine positive urine during treatment had additive interaction (RERI=256.46,AP=0.87,S=8.05) and multiplication interaction (OR=2.45,95％CI:1.71-3.49).Conclusion Insufficient dosage and morphine positive urine were significantly correlated with drop out of treatment in patients with access to methadone maintenance treatment.
