Health related quality of life on severe hand, foot and mouth disease patients
10.3760/cma.j.issn.0254-6450.2017.04.010
- VernacularTitle:手足口病重症患者健康相关生存质量评估
- Author:
Yaming ZHENG
1
;
Juan YANG
;
Qiaohong LIAO
Author Information
1. 中国疾病预防控制中心传染病预防控制处传染病监测预警国家重点实验室
- Keywords:
Hand,foot and mouth disease;
Severe;
Complication;
Health related quality of life
- From:
Chinese Journal of Epidemiology
2017;38(4):462-466
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the health related quality of life (HRQoL) for severe hand,foot and mouth disease (HFMD) patients with different complications.Methods A national telephone interview under the EQ-5D proxy2 questionnaire (EQ-SD and EQ-VAS),was conducted to obtain the HRQoL of lab-confirmed severe HFMD patients,aged between six months and five-year-olds from the national communicable disease surveillance system from January 1,2012 to December 31,2013.Results A total of 685 severe HFMD cases were included in the study.A total of 456 (66.6％) of them were males with 75.8％ of them younger than three years old.A total of 337 (49.2％) and 407 (59.4％) of the participants reported that they had problems in mobility or daily activities.A total of 569 (83.1％) and 616 (89.9％) of the cases reported having problems in pain/discomfort or anxiety/depression.The average EQ-5D and EQ-VAS scores were 0.58 ± 0.23 and 53.6 ± 25.7,both were positively associated with the duration of illness.Mean quality adjusted life years loss during the HFMD episode for the severe patients was (15.45 ± 13.75) years/1 000 persons.The QALY losses for severe patients with each of below complication were:respiratory diseases (11.17 ± 8.83) years/1 000 persons,aseptic meningitis (13.56 ± 11.99) years/1 000 persons,encephalitis/brainstem encephalitis/acute flaccid paralysis (AFP) (15.31 ± 12.63) years/1 000 persons,Myocarditis (17.28 ± 18.16) years/1 000 persons,pulmonary hemorrhage/pulmonary edema (17.34 ±14.98) years/1 000 persons,cardiopulmonary failure (25.47 ± 20.53) years/1 000 persons.Among patients with lab confirmed Entero virus A71 (EV71) (16.51 ± 14.48) years/l 000 persons,the QALY loss was seen higher than Coxsackie virus A16 (Cox A16) (13.02± 11.45) years/1 000 persons and other Enter virus (14.74 ± 14.22) years/1 000 persons (Z=11.83,P=0.003).Conclusion The HRQoL loss for severe HFMD patients substantially increased under complications exacerbation and related to the duration of illness.
