Progress of research on azole resistance in Aspergillus fumigatus
10.3760/cma.j.issn.0254-6450.2016.12.025
- VernacularTitle:烟曲霉对唑类药物耐药研究的最新进展
- Author:
Yong CHEN
1
;
Zhongyi LU
;
Yuan JIN
;
Li HAN
;
Liuyu HUANG
Author Information
1. 军事医学科学院疾病预防控制所医院感染监控中心
- Keywords:
Aspergillus fumigatus;
Azole drugs;
Drug resistance;
Epidemiology;
Evolution
- From:
Chinese Journal of Epidemiology
2016;37(12):1687-1692
- CountryChina
- Language:Chinese
-
Abstract:
Being an important clinical fungal pathogen,Aspergillus (A.)fumigatus can cause fatal invasive fungal infections.Azoles are the first line drugs in treating various Aspergillus-caused diseases.Worldwidely,reports related to azole resistance in A.fumigatus have been increasing which posing a threat on the effectiveness of clinically used azole and agricultural fungicides.Currently,it has become an important public health issue.In this review,we summarize findings from literature regarding the following areas:the occurrence of azole resistance in A.fumigatus,the molecular mechanisms of resistance,contributing factors for the emergence of azole resistance,evolution of resistant strains and related control and prevention measures.
