Association between parental exposure to environmental risk factors and the risk of childhood acute lymphoblastic leukemia
10.3760/cma.j.issn.0254-6450.2016.10.019
- VernacularTitle:孕期父母环境危险因素暴露与儿童急性淋巴细胞性白血病风险关系分析
- Author:
Jingwei ZHANG
1
;
Qiang ZENG
;
Liang ZHAO
;
Ming ZHANG
;
Li ZHANG
;
Qing GU
Author Information
1. 300070,天津医科大学研究生院
- Keywords:
Acute lymphoblastic leukemia;
Pregnancy environmental risk factors
- From:
Chinese Journal of Epidemiology
2016;37(10):1413-1416
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between parental environmental risk factors exposure and the risk for childhood acute lymphoblastic leukemia (ALL).Methods A total of 179 ALL children cases were selected in Tianjin Blood Disease Hospital and 136 healthy children matched by age,gender and living place were selected in 2015 for a case control study.The data were analyzed with univariate and multivariate non conditional logistic regression models.Results The results of multivariate logistic regression analysis indicated that sex,history of abortion,exposure in a smoking environment during pregnancy,catching a cold,taking antipyretic analgesics,maternal exposure to air purifying agent,father's occupational exposure to petroleum products and home decoration during pregnancy were associated with the risk of childhood ALL (P＜0.05) and the results of multivariate logistic regression analysis indicated that sex,history of abortion,catching a cold,father's occupational exposure to petroleum products and home decoration during pregnancy were associated with the risk of childhood ALL (P＜0.05).Conclusion The five factors including sex,history of abortion,catching a cold,father's occupational exposure to petroleum products and home decoration during pregnancy were risk factors for childhood ALL.
