Association between serum albumin and cognitive performance in elderly Chinese
10.3760/cma.j.issn.0254-6450.2016.10.001
- VernacularTitle:中国8个长寿地区65岁及以上老年人群血浆白蛋白水平与认知功能关系的研究
- Author:
Zhaoxue YIN
1
;
Jinglei WANG
;
Yuebin LYU
;
Jiesi LUO
;
Yi ZENG
;
Xiaoming SHI
Author Information
1. 中国疾病预防控制中心慢性病防治与社区卫生处
- Keywords:
Cognitive function;
Elderly;
Albumin;
Health aging
- From:
Chinese Journal of Epidemiology
2016;37(10):1323-1326
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore association between serum albumin level and cognitive performance in elderly Chinese.Methods All the subjects aged ≥65 years in the 8 longevity areas in Chinese longitudinal health longevity survey (CLHLS) were invited to participate the biomedical in-depth CLHLS study,information about subjects' demographic characteristics,lifestyle,prevalence of diseases and health status was collected through household-interview.The cognitive performance was assessed with Mini Mental State Evaluation (MMSE) scale.Health examination was conducted by medical personnel and fasting venous blood samples were collected to detect the levels of triglycerides,total cholesterol,fasting glucose,creatine and blood albumin.MMSE score was compared and the trend was analyzed with generalized linear model.Association between albumin concentration and cognitive impairment was analyzed by logistic regression model.Results Generalized linear model showed that adjusted MMSE score increased from 23.22 in the lowest quartile group to 25.07 in the highest quartile group (P for linear trend ＜0.001).Logistic regression analysis results showed that the higher albumin level was associated with the lower risk of cognitive impairment (P＜ 0.001),the OR decreased linearly with the increasing level of albumin (P＜0.01),with the OR (95％CI) for the lower,higher and highest quartile groups was 0.64(0.45-0.91),0.60(0.40-0.89) and 0.43 (0.27-0.69),respectively,compared with the lowest quartile group.Conclusion High level of serum albumin was associated with low risk of cognitive impairment.
