Clinical and Pathological Study After Ligation of Common Carotid Artery in the Rat.
- Author:
Jeong Nan CHO
1
;
Seong Ho KIM
;
Kwan Tae KIM
;
Youn KIM
Author Information
1. Departments of Neurosurgery, College of Medicine, Chungnam National Uiversity, Taejon, Korea.
- Publication Type:Original Article
- MeSH:
Animals;
Arteries;
Brain;
Carotid Artery, Common*;
Cerebral Infarction;
Dyskinesias;
Infarction;
Ligation*;
Mortality;
Paresis;
Rats*;
Seizures
- From:Journal of Korean Neurosurgical Society
1991;20(12):1069-1075
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study examined the late pathological finding, clinical manifestation, and mortality in thirty-two rats with cerebral infarction induced by common carotied artery ligation. Thirty-two rats were divided into three group : Group A-a unilateral common carotid artery ligation group of twelve animals, Group B-a total common carotid artery ligation one side and partial common carotid artery ligation another side of eighteen animals, and Group C-bilateral common carotid arteries ligation of two animal. All animals surviving for 3 weeks were sacrified by intracardial injection of 2 M KCI 5cc and 2.5cc of 2% T.T.C. solution was infused into each common carotid arteries. The brain was rapidly rmoved and sectioned coronally and examined with the aid of a stereoscopic microscope for degree of T.T.C. stain and infarction. Brain was fixed and examined histologically. The results were as follows : 1) Mortality rate of each group : a unilateral common carotid artery ligation group was 16.67%, a total. Common carotid artery ligation on side and partial common carotid artery ligation another side group was 77.78%, and bilateral common arteries ligation group was 100%. 2) Clinical manifestation was showed as follows : hemiparesis, circling movement, abnormal seizure like activity, and ptosis. 3) Percent hemispheric volume infarction(%HVI) was 40%(mean value) in unilateral total common carotid artery ligation and 60% in total ligation one side and 46.25% in partial ligation another side. 4) The pathological change was signigicantly visible in bilateral ligation group.
