Association between genetic variants in p53 binding sites and risks of breast cancer in Chinese population
10.3760/cma.j.issn.0254-6450.2016.08.002
- VernacularTitle:p53靶基因结合区遗传变异与中国人群乳腺癌遗传易感性的关联研究
- Author:
Wei CHEN
1
,
2
;
Yi ZHANG
;
Ying ZHU
;
Yang YANG
;
Yajie GONG
;
Xiaoping MIAO
;
Rong ZHONG
Author Information
1. 430030 武汉,华中科技大学同济医学院公共卫生学院流行病与卫生统计学系
2. 519000 珠海市慢性病防治中心预防保健部
- Keywords:
Breast cancer;
p53 binding site;
rs1295925
- From:
Chinese Journal of Epidemiology
2016;37(8):1063-1068
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between breast tissue specified variants in p53 binding sites and the risk of BC in Chinese women.Methods ChIP-seq database on p53 binding sites in MCF-7 cell lines was extracted to identify the possible variants in p53 target genes.A hospital-based case-control study was then performed to investigate the association between variants in p53 binding sites and the risk of BC in a Chinese women population.Results Three variants were identified from the bioinformatics analysis.A total of 1 274 BC cases and 1 255 frequency-matched cancer-free controls were included in this case-control study.The average age was comparable between the case and the control groups,with the P value as 0.318.Meanwhile,distributions on menopausal status,smoking and alcohol intake between cases and controls were similar with the P values as 0.539,0.258 and 0.131,respectively.The genotype distribution of rs1295925 was significantly different between the case and the control groups.Individuals that carrying rs1295925-CT and rs1295925-TT genotypes were significantly associated with an increased BC risk when compared with rs1295925-CC genotype after adjustment of age,menopausal status,smoking and alcohol intake (0R=1.32,95％ CI:1.07-1.62 and OR=1.41,95％CI:1.13-1.78,respectively).Positive associations were also observed under the allelic,dominant and additive models.Conclusion rs1295925 which located in VMP1 gene was associated with increased BC risk in the Chinese women population.
