Log-linear model used in the hybrid design of case-parents triad/control-mother dyad
10.3760/cma.j.issn.0254-6450.2016.06.029
- VernacularTitle:对数线性模型在病例-父母/对照-母亲混合设计中的应用
- Author:
Weijun PENG
1
;
Heng ZHANG
;
Yingxue LI
;
Chenyang LI
;
Weirong YAN
Author Information
1. 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系
- Keywords:
Hybrid design;
Log-linear model;
Gene polymorphism
- From:
Chinese Journal of Epidemiology
2016;37(6):886-890
- CountryChina
- Language:Chinese
-
Abstract:
This study introduced the application of a log-linear model in the hybrid design of case-parents triad/control-mother dyad.Data related to the association between cleft lip with palate (CLP) and methylenetetrahydrofolate reductase (MTHFR) gene A1298C diversity was analyzed.Log-linear model based on likelihood ratio tests (LRTs) was used to analyze the relationships between mother,offspring genotypes and CLP.Data from our study noticed that children of mothers carrying the CC genotype presented a lower risk of CLP,comparing with the children of mothers carrying the AA genotype,with S2=0.45 (95％CI:0.26-0.79).Offspring that carrying the AC genotype presented a lower risk of CLP,comparing with the offspring that carrying the AA genotype,with R1 =0.69 (95％CI:0.48-0.97).However,no other types of relationships were found.The power of hybrid design was greater than the case-parents study (0.86＞0.78).MTHFR A1298C polymorphism seemed to have played an important role in the etiology on both cleft lip and palate.Data from the hybrid design and the log-linear model could help researchers to explore the effects of genotypes from both mothers and the offspring.This study design would present stronger power than the regular case-parents studies thus suitable for studies on the etiology of diseases in early lives,as birth defects.
