Association between β-arrestin2 genetic polymorphism and response to methadone maintenance treatment in heroin-dependent patients in Han population in Hunan province
10.3760/cma.j.issn.0254-6450.2016.06.026
- VernacularTitle:β-arrestin2基因多态性与湖南省汉族海洛因成瘾者美沙酮维持治疗反应的关联分析
- Author:
Rui LUO
1
;
Xiangling FENG
;
Xi LUO
;
Zhisheng LIU
;
Peiwu HU
;
Shu LIU
;
Xingli LI
Author Information
1. 中南大学湘雅公共卫生学院流行病与卫生统计教研室
- Keywords:
Methadone maintenance treatment;
ARRB2 genes;
Single nucleotide polymorphism;
Treatment response
- From:
Chinese Journal of Epidemiology
2016;37(6):872-875
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distributions of three single nucleotide polymorphisms (SNPs) in β-arrestin2 (ARRB2) which including rs3786047,rs1045280 and rs2036657 and to elucidate the relationship between these SNPs and response to methadone maintenance treatment (MMT) among heroin-dependent patients of Han ethnicity population in Hunan.Methods Han MMT patients were recruited in four random-chosen MMT clinics from Hunan province.Demographics,history of drug-use and MMT were recorded.ARRB2 SNPs were genotyped to determine the association between SNPs and response to MMT.Results Distributions of the three SNPs were in Hardy-Weinberg equilibrium in both groups (responders vs.non-responders).There was no statistical significance in the distribution frequency of genotype on rs3786047 (x2=0.486 2,P=0.784),rs1045280 (x2=1.591 9,P=0.451) and rs2036657 (x2=1.061 5,P=0.588) in ARRB2 among the responders or the non-responders.Conclusion Associations between the ARRB2 genotypes,rs3786047,rs1045280 and rs2036657,and MMT response in Han MMT patients in Hunan province did not appear.
