Relationship between N-nitrosodimethylamine and risk of digestive tract cancers: a Meta analysis based on cohort studies
10.3760/cma.j.issn.0254-6450.2016.05.029
- VernacularTitle:N-亚硝胺与消化道恶性肿瘤发生风险的关系:基于队列研究的Meta分析
- Author:
Juan CUI
1
;
Xiaomin GUO
;
Heling BAO
;
Jibin TAN
Author Information
1. 中国疾病预防控制中心慢性非传染性疾病预防控制中心
- Keywords:
N-nitrosodimethylamine;
Esophageal cancer;
Gastric cancer;
Cohort;
Meta analysis
- From:Chinese Journal of Epidemiology
2016;37(5):725-729
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between N-nitrosodimethylamine (NDMA) and the risk of digestive tract cancers.Methods The papers about the relationship between NDMA and the risk of digestive tract cancers published from 1980 to 2012 were retrieved following databases:Chinese BioMedical Literature Database (CBM),the Chinese Journal Full-text Database (CNKI),Wanfang Database,PubMed and EBSCO.The fix and random effect model was used and statistical analyses were conducted by using RevMan 5.1 software.Results Thirteen papers were found,in which 7 about digestive tract cancers were used in this Meta analysis.The NDMA had significant positive effect on the incidence of digestive tract cancers (RR=1.12,95％ CI:1.03-1.21).The relationship between NDMA and esophageal cancer was not significant (RR =1.18,95 ％CI:0.98-1.41) but NDMA could increase the risk of gastric cancer (RR=1.08,95％ CI:1.00-1.18).For the subtypes of esophageal and gastric cancer,NDMA had positive relationship with esophageal squamous cell carcinoma (RR=l.72,95％ CI:1.01-2.96),but had no significant relationship with esophageal adenocarcinoma,cardiac carcinoma and gastric adenocarcinoma.Conclusion The population-based cohort studies have showed that the NDMA could significantly increase the risk of digestive tract cancers,but the effects differed with subtypes of esophageal and gastric cancer.However,it is necessary to collect more evidence due to the limited studies and obvious differences in the study design,sampling and exposure measurement of these cohort studies.
