Risk factors of 125 cases of neonatal congenital hypothyroidism during perinatal period
10.3760/cma.j.issn.0254-6450.2015.07.018
- VernacularTitle:125例新生儿先天性甲状腺功能减低症围产因素分析
- Author:
Jinfu ZHOU
1
;
Jinying LUO
;
Hong ZHAO
;
Jing WANG
;
Feng LIN
;
Honghua ZHANG
;
Yueqing SU
;
Yao CHEN
;
Yinglin ZENG
;
Qingying LIN
;
Wenbin ZHU
Author Information
1. 福建省妇幼保健院福建医科大学教学医院福建省新生儿疾病筛查中心
- Keywords:
Congenital hypothyroidism;
Perinatal;
Case-control study
- From:Chinese Journal of Epidemiology
2015;(7):747-751
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the relationship between perinatal factors and congenital hypothyroidism(CH)and provide scientific evidence for the prevention of CH. Methods A case-control study was conducted among 125 neonates with CH (case group) and 375 neonates without CH(control group)in Fujian Neonatal Screening Center from January in 2012 to December in 2013. Univariate and multivariate logistic regression analysis were performed to identify the risk factors to CH during perinatal period. Results Univariate logistic regression analysis indicated that compared with control group,gestational hypertension,gestational diabetes mellitus,gestational thyroid disease and older age of mother were the risk factors to CH,the difference was statistically significant (P<0.05) and the risk of CH was higher in female babies,preterm babies,post-term babies low birth weight babies,macrosomia,twins,babies with birth defects and infection in cases group than those in control group,the difference was statistically significant (P<0.05). Multivariate logistic analysis showed that older age of mother(OR=2.518,95%CI:1.186-5.347), gestational diabetes mellitus(OR=1.904,95%CI:1.190-3.045),gestational hypothyroidism or hyperthyroidism(OR=12.883 and 30.797,95%CI:2.055-80.751 and 3.309-286.594),preterm birth (OR=4.238,95%CI:1.269-14.155),and post-term birth(OR=12.799,95%CI:1.257-130.327),low birth weight(OR=3.505,95%CI:1.059-11.601),macrosomia(OR=3.733,95%CI:1.415-9.851), twin or multiparous delivery(OR=5.493,95%CI:1.701-17.735),birth defects(OR=3.665,95%CI:1.604-8.371)and fetal distress(OR=3.130,95%CI:1.317-7.440)were the high risk factors to CH (P<0.05). Conclusion CH was correlated with mother’s age,gestational diabetes,gestational thyroid disease as well as neonate’s birth weight and gestational age,foetus number,fetal distress and other complicated birth defects at certain degree. More attention should be paid to perinatal care to reduce risk factors and the incidence of CH.
