Infection status of enterovirus 71 and coxsackievirus A16 among children receiving health examination for child care setting entrance in Beijing and their related medical care seeking ;practice
10.3760/cma.j.issn.0254-6450.2015.07.014
- VernacularTitle:北京市入托体检健康儿童肠道病毒71型和柯萨奇病毒A组16型感染状况及就诊行为调查
- Author:
Xiaoli WANG
1
;
Changying LIN
;
Haiyan ZHANG
;
Jianxin MA
;
Chao LI
;
Jie LI
;
Lei JIA
;
Yang YANG
;
Yiwei DU
;
Zhichao LIANG
;
Quanyi WANG
;
Xiong HE
Author Information
1. 100013,北京市疾病预防控制中心
- Keywords:
Hand foot and mouth disease;
Enterovirus 71;
Coxsackie virus A16
- From:
Chinese Journal of Epidemiology
2015;(7):730-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the infection status of enterovirus 71(EV71) and coxsackievirus A16(Cox A16) among children receiving health examination for child care setting entrance in Beijing and their related medical care seeking practice and provide evidence for the estimation of disease burden caused by hand foot and mouth disease(HFMD). Methods Serological survey was conducted in the local children receiving health examination for child care setting entrance. Enzyme-linked immunosorbent assay (ELISA) was conducted to detect anti-EV71 and anti-Cox A16 IgG and IgM. Results A total of 813 children were surveyed(mean age:3.5±1.0 year old). The seropositive rate was 61.9%and 4.4%for anti-Cox A16 IgG and IgM. The seropositive rate was 9.3% and 1.1% for anti-EV71 IgG and IgM. No significant difference was observed in sex specific seropositive rate (P>0.05). However,significant differences were found in seropositive rate among different age groups(P<0.05). Among the children who were anti-Cox A16 positive, 7.8%had ever had rashes on their hands and feet,mouth or buttocks(HFMD-like rashes). Among the children who were anti-EV71 positive,10.7%had ever had HFMD-like rashes. For the children who were anti-Cox A16 or anti-EV71 positive,only 7.1% were brought to see doctors by their parents. However,among the seropositive children with rashes,80.5% were brought to see doctors. Conclusion In the healthy children at the age to go to child care setting in Beijing,most had ever infected with Cox A16. The anti-EV71 positive rate was much lower than the anti-Cox A16 positive rate. It was necessary to strengthen the prevention and control of EV71 infection in child cares settings.
