Mediating effect of blood lipids on correlation between body fat and blood pressure among ;overweight adults
10.3760/cma.j.issn.0254-6450.2015.07.006
- VernacularTitle:超重/肥胖成年人体脂与血压关联中血脂中介效应的分析
- Author:
Yide YANG
1
;
Lianguo FU
;
Zhenghe WANG
;
Shuo WANG
;
Xiangkun MENG
;
Rui MA
;
Dongmei MA
;
Jun MA
Author Information
1. 100191北京大学公共卫生学院北京大学儿童青少年卫生研究所
- Keywords:
Obesity;
Blood lipids;
Percentage of body fat;
Blood pressure;
Mediating effect
- From:
Chinese Journal of Epidemiology
2015;(7):691-694
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the mediating effect of blood lipids on the correlation between body fat and blood pressure among overweight adults. Methods Overweight and obese subjects aged 20-55 years who had lived in Beijing for at least 1 year were recruited in this study, Body mass index(BMI)was used as a screening indicators. The percentage of body fat(PBF)was measured for the subjects by using dual energy X-ray absorptiometry(DXA). Mediating effect analysis was conducted to analyze the mediating effect of blood lipids on correlation between PBF and systolic blood pressure(SBP)as well as diastolic blood pressure(DBP). Results After adjusting for age,PBF was positively correlated with SBP and DBP in both males(β=0.208 3,β=0.205 2, P<0.001)and females(β=0.188 4,β=0.209 6,P<0.001). In male subgroup,PBF was negatively correlated with HDL-C level,but positively correlated with LDL-C level(β=-0.142 2,P<0.01 andβ=0.180 5,P<0.001),while in female subgroup,PBF was positively correlated with both TC level and LDL-C level(β=0.172 1,P<0.001 and β=0.233 5,P<0.001). With PBF controlled,TC and TG levels were positively correlated with DBP in both males and females(β=0.095 6,0.090 5 for males,β=0.117 6,0.083 1 for females,P<0.05),and TG level was positively correlated with SBP in females(β=0.127 2,P<0.001). Further analysis indicated there was a significant mediating effect of LDL-C on correlation between PBF and DBP in females,with the mediating effect value of 0.019 4 (P<0.05). The ratio of mediating effect was 9.26%. Conclusion PBF was positively correlated with blood pressure,but blood lipids had no mediating effect on the correlation between PBF and blood pressure in males,while LDL-C level had mediating effect on PBF and blood pressure in females.
