Epidemiological study on antibiotic resistance among Helicobacter pylori in Taizhou district, Zhejiang,2010-2013
10.3760/cma.j.issn.0254-6450.2014.06.019
- VernacularTitle:浙江省台州地区2010-2013年幽门螺杆菌常用抗生素耐药监测
- Author:
Tiangan YANG
1
;
Hongzhang LI
;
Jiaoe CHEN
;
Wanli ZENG
;
Junliang MAO
;
Zhihua ZHANG
;
Junhua YANG
;
Ningmin YANG
;
Miaoying TU
;
Jianzhong ZHANG
Author Information
1. 317100,浙江省三门县人民医院
- Keywords:
Helicobacter pylori;
Antibiotic;
Drug resistance
- From:
Chinese Journal of Epidemiology
2014;(6):704-707
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the infection status of Helicobacter pylori (H. pylori) and sensitivity to commonly used antibiotics in Taizhou district,Zhejiang province. Methods 39 099 cases aged between 5 and 95 years old(mean as 48.42 years)were involved during January 2010 to December,2013 for this study. Sex ratio was 1 ∶ 0.95. Yearly distribution of the number of cases were 5 031,6 709,11 902 and 15 457 in 2010,2011,2012 and 2013,respectively. Gastric mucosal specimens were collected and H. pylori strains were isolated and cultured in the same platform in Zhiyuan Medical Inspection Institute of Hangzhou. Resistance tests of all the H. pylori isolates were performed to 6 commonly used antibiotics:metronidazole,clarithromycin,amoxicillin,gentamicin, levofloxacin and furazolidone with the agar dilution method. The antibiotic resistance rates of H. pylori strains isolated during year 2010-2013 and the changing trends were analyzed. Results Resistance rates to levofloxacin and clarithromycin kept at higher level and the highest was in 2011 and then decreased in both 2012 and 2013 (P<0.01). The resistance rates to both levofloxacin and clarithromycin reached the highest in 2011(P<0.01),and decreased thereafter,with no significant change in 2013 to 2012(P>0.05). Conclusion Antibiotic resistance rate against metronidazole for HP isolate was highest. Resistance rate against amoxicillin and furazolidone,gentamicin was low. Clinical treatment should choose amoxicillin and furazolidone,gentamicin. The resistance rates to levofloxacin and clarithromycin had been seen at a significantly downwarding trend since 2011. However,the combined resistance rates to levofloxacin and clarithromycin did not seem to reduce since 2012.
