The relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia
10.3760/j.issn:0254-6450.2001.01.010
- VernacularTitle:低密度脂蛋白受体基因多态性与高脂血症的关系
- Author:
Aiping LIU
1
;
Siyan ZHAN
;
Liming LI
Author Information
1. Beijing Medical University
- From:
Chinese Journal of Epidemiology
2001;22(1):30-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia in the population with essential hypertension. Methods People with different lipid levels including 107 hyperlipidemia，104 at margin level and 108 normal were recruited in the study. Their polymorphisms of LDL-R gene were analyzed using PCR-RFLP. Results There were three kinds of genotype: (+/+)、(+/-)、(-/-). In male, the frequencies of the(+/-)in three study groups were shown as follows: 41.18% in hyperlipidemia, 46.15% in margin level, 19.05% in normal lipid. The frequency of (+) allele was significantly higher in hyperlipidemia than that in normal lipid (24.51%,25.00% and 11.11%, respectively). In women, the differences were not statistically significant. The nonconditional univariate and multivariate logistic regression analysis demonstrated that (+) allele of AvaⅡ polymorphism of LDL-R was a genetic marker of male's hypercholesterolemia. Conclusions The frequency of (+/-) hyperlipidemia in males was higher than that in normal lipid group and the (+) allele in male hyperlipidemia was significantly more frequant seen than that in normal lipid group. These results suggested that polymorphisms of LDL-Rgene might play an independent role of risk factor for hyperlipidemia.
