GLTSCR1, ATM, PPP1R13L and CD3EAP Genetic Variants and Lung Cancer Risk in a Chinese Population
10.1007/s11596-018-1938-6
- Author:
Jiao-Yang YIN
1
;
Ye-Gang MA
;
Vogel ULLA
;
Dong-Hui LIU
;
Zhen-Xiang SUN
Author Information
1. Key Laboratory of Environment and Population Health of Liaoning Education Ministry(Shenyang Medical College)
- Keywords:
GLTSCR1,ATM,PPP1R13L,CD3EAP;
genetic variants;
smoking duration;
interaction;
lung cancer,Chinese
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2018;38(4):734-740
- CountryChina
- Language:Chinese
-
Abstract:
Genetic variants in glioma tumor suppressor candidate region gene 1 (GLTSCR1)and ATM serine/threonine kinase (ATM) have been associated with various cancer risks.Epidemiological studies also revealed the association of variants of GLTSCR1 and ATM genes with different brain tumors.However,little is known about the relationship between both gene polymorphisms and lung cancer risk.We conducted a Chinese hospital-based casecontrol study involving 384 lung cancer cases and 387 cancer-free controls.No significant differences in the single polymorphism (GLTSCR1 rs1035938 and ATM rs11212592)association were found in five genetic models (co-dominant,dominant,recessive,overdominant and log-additive models) (adjusted by smoking duration).Join effect of three SNPs (PPP1R13L rs1970764,CD3EAP rs967591,GLTSCR1 rs1035938) on chromosome 19q 13.3 showed that the designated haplotype2 (rs 1970764
