Polymorphism of OAS2 rs739901 C/A Involves the Susceptibility to EV71 Infection in Chinese Children
10.1007/s11596-018-1925-y
- Author:
Yu-Xia TAN
1
;
Hui WANG
;
Hua LV
;
Pei-Pei LIU
;
Shun-Gang XIA
;
Yu WANG
;
Gao-Yan WANG
;
Ya GUO
;
Ye-Dan LIU
;
Cheng-Qing YANG
;
Li-Ping CHEN
;
Zong-Bo CHEN
Author Information
1. Department of Pediatrics
- Keywords:
enterovirus-71 infection;
OAS2 rs739901 C/A;
polymorphism
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2018;38(4):640-647
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed to assess the relationship of OAS2 rs739901 5'-flanking C/A polymorphisms with the susceptibility to Enterovirus-71 (EV71) infection.We investigated 294 hand-foot-mouth disease (HFMD) Chinese children with EV71 infection (165 mild cases and 129 encephalitis cases).The improved multiplex ligation detection reaction (iMLDR) technique was used to test the genotypes.In EV71-infected patients,the CA genotype distribution (P=0.007),A allele frequency (OR 1.32,95％ CI 1.0-1.7,P=0.034)and CA+AA carriage frequency (P=0.003) of OAS2 rs739901 5'-flanking were obviously elevated as compared with controls,but there were no statistically significant differences between mild cases and encephalitis cases.In EV71-infected patients,the counts of white blood cells (P=0.034) and blood glucose concentrations (P=0.042) were raised in A carriers (CA+AA).Among different genotypes of encephalitis cases,the contents of cerebrospinal fluid (CSF) showed no significant differences.IFN-γ levels in EV71-infected patients were higher than those in controls (mild group vs.control group,P＜0.01;encephalitis group vs.control group,P＜0.001).In encephalitis cases,IFN-γ levels were reduced (P＜0.05) in A carriers compared to CC genotype,however,there were no significant differences between genotypes CA and AA (P=0.226).These findings suggest that OAS2 rs739901 5'-flanking C/A genetic polymorphisms involve the susceptibility to EV71 infection,and A allele might be a risk factor of the susceptibility to EV-71 infection.
