A Study of Topical Corticosteroid Effect on the Rat Skin Mast Cell.
- Author:
Seok Ho KIM
;
Eil Soo LEE
;
Chin Yo CHANG
- Publication Type:Original Article
- Keywords:
Mast Cell;
Corticosteroid
- MeSH:
Adrenal Cortex Hormones;
Animals;
Desoximetasone;
Mast Cells*;
Microscopy;
Rats*;
Skin*
- From:Korean Journal of Dermatology
1988;26(1):22-27
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effect of long-term topical application of corticosteroids on rat cutaneous mast cells was examined under the light microscopy. Two potent corticosteroids, 0.05% clobetasol-17-propionate and 0.25% desoxymethasone, produced a remarkable decresse greater than 50% of pretreatment mast cell number by two weeks. Wheress a less potent corticosteroid, 0.1% hydrocotisone-17-valerate, produced a remarkable decrease greater than 50% of pretreatment mast cell number by four weeks. All corticosteroids produced a remarkable decrease greater than 80% of pretreatment mast cell number by six weeks. These results suggest that long-term topical application of corticosteroids may have the deleterious effects on cutsneous mast cells.
