A Study on the Expression of Interleukin(IL)-10 and IL-12 P35, P40 mRNA in the Psoriatic Lesions
- Author:
Jiqun CHENG
1
;
Yating TU
;
Jiawen LI
;
Changzheng HUANG
;
Zhixiang LIU
;
Daofan LIU
Author Information
1. Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2001;21(1):86-88
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the possible role of interleukin (IL)-10 and IL-12 in the pathogenesis of psoriatic lesions and to supply theoretical basis for the gene therapy for psoriasis, the expression of IL-10 and IL-12 P35, P40 mRNA in 12 cases of psoriatic lesions and 6 normal skin tissues was detected by using RT-PCR technique. The results showed that the expression of IL-10 mRNA in the psoriatic lesions was significantly lower than that in the normal skin tissues (P<0.001). The expression of IL-12 P35 was positive both in the psoriatic lesions and in the normal skin tissues. IL-12 P40 mRNA was expressed positively only in the psoriatic lesions but negatively in the normal skin tissues. It was suggested that IL-12 might take an important role in the occurrence and progression of psoriasis, but IL-10 might have certain role in the regression of psoriasis.
