Studies on Metal Phthalocyanine as a Dual Functional Mimic Enzyme
- Author:
Qing FENG
1
;
Li LIU
;
Yongyan HE
;
Hailong WANG
;
Mingyuan WU
;
Fuming MEI
Author Information
1. Tongji Medical College
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2001;21(1):13-16
- CountryChina
- Language:Chinese
-
Abstract:
Four phthalocyanines (iron tetracarboxylphthalocyanine, copper tetracarboxylphthalocyanine, manganese tetracarboxylphthalocyanine, cobalt tetracarboxylphthalocyanine) were used as dual functional mimic enzymes of superoxide dismutase (SOD) and catalase (CAT). The first function, eliminating O2－, was proved by using riboflavine-methionine photoreduction method in the concentration range of 10－5 to 10－6 mol/L. The second function, clearing out H2O2, was demonstrated by means of spectrophotometry with the decomposing percentage being increased with the increase of the concentration of the imitating compounds. Measurements of metal phthalocyanines, SOD and CAT by the liver homogenate technique of mice showed that they had obvious action of decreasing the lipid peroxidation.
