The Role of Protein Kinase C and Its Effect on GHRH in the Regulation of Hormone Secretion by Somatotrophinomas
- Author:
Kui LIU
1
;
Xiangjun BAI
;
Ting LEI
;
Delin XUE
;
Qin LIU
Author Information
1. Tongji Hospital Tongji Medical University
- Keywords:
somatotrophinoma;
phorbol ester;
growth hormone releasing hormone;
signal transduction
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2000;20(1):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Phorbol ester-induced release of growth hormone (GH) and prolactin (PRL) from human somatotrophic tumors was examined in vitro. 12-O-tetradecanoyl-phorbol-13- acetate (TPA)strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH). In contrast, staurosporine exerted a variable inhibitory effect on GH release. There was no correlation between such effects and gsp mutations.The findings suggested that TPA doesn't act directly through cAMP signal transduction system.
