Alteration of Multiple Systems in Offspring After Prenatal Stress
10.3969/j.issn.1673-6273.2007.05.038
- VernacularTitle:孕期应激对子代影响及相关机制的探讨
- Author:
Ying-Gui XIE
1
;
Xiao-Ye MO
;
Qi-Ben WANG
;
Zheng LI
Author Information
1. 湘南学院
- Keywords:
Prenatal Stress;
Offspring;
Neusopeptide Y;
Dopaminergic (DA-ergic) System
- From:
Progress in Modern Biomedicine
2007;7(5):749-753
- CountryChina
- Language:Chinese
-
Abstract:
This paper, from the aspects of neuroendocrine, emotion, learning etc, analyzed comprehensively the characteristics of the influence of prenatal stress (PS) on offspring, including intensity of PS, timing of exposure and individual differences. Despite the variety in methodology, most studies on it indicate that the prenatal stressful events lead to offspring's increased plasma glucocorticoid (GC) level, more depressed-related behaviors and impaired learning abilities. Although mechanism of prenatal stress is still unclear, most studies show that it is concerned with hypothalamio-pituitary-adneral (HPA) axis,dopaminergic (DA-ergic) system, neuropeptide Y (NPY)and serotoninergic (5-HT ergic) system. Moreover, further studies are proposed to pay more attention to the relationship and interaction of various related substances.
