Genetic variants in the tumor necrosis factor receptor 2 gene in patients with Systemic lupus erythematosus

VernacularTitle:TNFR2基因多态性与SLE的相关性研究
Author: Zhi-Hua YIN ¹ ; Zhi-Zhong YE ; Jun-Han ZHUANG ; Da-Qiang GAN ; Xun WANG ; Xiu-Xia LUO
Author Information

1. 广东省深圳市第四人民医院香蜜湖风湿病分院
Keywords: Systemic lupus erythematosus; Tumor necrosis factor receptor 2; Polymorphism
From: Progress in Modern Biomedicine 2006;6(10):34-36
CountryChina
Language:Chinese
Abstract: In this paper, we designed to investigate the frequencies of tumor necrosis factor receptor 2 (TNFR2) polymorphisms at nt587 and nt694 in south Chinese SLE patients and healthy individuals and explore whether genetic variants in TNFR2 gene is involved in the pathogenesis of SLE. The results showed that the nt587G allele frequency was 21.1% in the 128 SLE patients and the allele frequency was 13.0% in the 135 healthy individuals, the former was significantly higher than the latter in the allele frequency (P ＜ 0.05). People with the nt587 G variant showed high risk to SLE. The frequency of nt694 was slightly but not statistically significantly increased in SLE patients compared with healthy controls(16.0% versus 11.9%, P= 0.149). These results indicate that the polymorphism at nt587 of TNFR2 is associated with the south Chinese SLE patients. The polymorphism at nt694 is not associated with SLE.