Effect of positive pressure ventilation on radiosensitivity of human pr imary lung cancers
10.3321/j.issn:1000-5404.2001.05.033
- VernacularTitle:BiPAP呼吸机正压给氧对增强肺癌放疗疗效的随机对照试验
- Author:
Wei XIONG
1
;
Han-Fang SHEN
;
Wei-Dong ZHANG
Author Information
1. Southwest Hospital The Third Military medical University
- From:Journal of Third Military Medical University
2001;23(5):588-590
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of positive pressure ventilation on radiosensitivity of the patients suffering from primary lung cancer. Methods Thirty cases of lung cancer were randomly divided into two groups: ① combining therapy group: patients treated with posi tive pressure ventilation using BiPAP respirator and radiotherapy;② simple radi otherapy group. The changes of PaO2, SaO2, blood white cells and the cellula r immunological function were observed before and after treatment. Resul ts Nasal or naso-facial positive pressure ventilation with BiPAP respi rator increased PaO2 significantly with the maximum of 7.5 kPa, SaO2 was ma inteined at above 95%. No significant change for the cellular immunological func tion was found in the combining therapy group （P>0.05）and only one patient with leukopenia（6.7%）. But in the radiotherapy group, the lymphocyte transfor mation efficiency and the ratio of CD4/CD8 were obviously decreased（P<0 .01), and leukopenia was found in 5 cases（33.3%）. Conclusion Nasal or naso-facial positive pressure ventilation with BiPAP respirator could improve the effect of radiotherapy for lung cancers. It could also increase PaO 2 significantly and has protective rote to the marrow and cellular immunologic al function of the patients.
