Clinical significances of growth hormone and growth hormone binding pro tein determination in patients with obstructive jaundice
10.3321/j.issn:1000-5404.2001.05.029
- VernacularTitle:阻塞性黄疸患者生长激素/生长激素结合蛋白检测的临床意义
- Author:
Yong AN
1
;
Ping BIE
;
Bing LIU
;
Li CHEN
;
Ben-Li HAN
Author Information
1. Southwest Hospital, Third Military Medical College
- From:Journal of Third Military Medical University
2001;23(5):579-581
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes and clinical s ignificances of serum growth hormore (GH) and GH binding protein (GHBP) in patie nts with obstructive jaundice (OJ). Methods Serum levels of GH, GHBP, insulin-like growth factor-Ⅰ (IGF-Ⅰ), endotoxin, prealbumin concentr ation and liver function in 60 male in patients with OJ were detected 1 d preope ratively and 1, 3, 7 d postoperatively. And 40 male patients with simple gallbla dder stone hospitalized in the same period were served as control. Resu lts The levels of GH, GHBP and IGF-Ⅰ were significantly lower in pati ents with obstructive jaundice than in control group(P<0.01), which was corr elated with the levels of bilirubin, endotoxin and prealbumin (P<0.01). Conclusion The obviously downregulation of GH/GHBP axis in patients with OJ probably results from the inbibition of expression of GH receptor due t o nutritional dysfunction and endotoxemia, and further aggravate the nutritional dysfuction and endoxemia, which may be one of the important factors in the path ophysiological changes of OJ.
