Experimental study of intracerebral transplantation of TH gene modified astrocytes for treating Parkinson's disease
10.3321/j.issn:1000-5404.2001.05.021
- VernacularTitle:TH基因修饰的胶质细胞脑内移植治疗帕金森病的实验研究
- Author:
Jun LIU
1
;
Ke-Cheng ZHANG
;
Wen-Qin CAI
Author Information
1. Xinqiao Hospital, Third Military Medical University
- From:Journal of Third Military Medical University
2001;23(5):556-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of tyrosine hydroxy lase (TH) gene in the treatment of Parkinson's disease (PD) by using ex vivo gene transfer. Methods After the construction of TH gene in a retroviral vector, the astrocytes were cultured with the supernatant containing the recombinant DNA and then grafted into the cerebrum of PD rats. The reduction of the rat rotation beharior was evaluated. Results The rotati on of PD rats was markedly improved in the rats with ex vivo gene transfer. Conclusion TH has an obvious efficiency on the treatment of PD and the astrocytes can be used as effective gene transfer cells.
