Effect of portal vein blocking on permeability of the intestinal mucosa in pigs
10.3321/j.issn:1000-5404.2001.04.020
- VernacularTitle:猪单纯门静脉血流阻断对肠粘膜通透性影响的研究
- Author:
Jian-Yong ZHAO
1
;
Jia-Hong DONG
;
Guo-Qing ZHAN
;
Huai-Zhi WANG
;
Zhan-Yu YANG
Author Information
1. 第三军医大学附属西南医院
- From:Journal of Third Military Medical University
2001;23(4):432-433
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of portal vein blocking on the permeability of the intestinal mucosa in pigs. Methods Healthy Rongchang pigs were divided into 3 groups: ① sham operation group(SO), ② portal vein clamping for 45 min group (PVC-45'), ③ portal vein clamping for 60 min group (PVC-60'). Urine lactulose/mannitol(L/M) ratio was measured after portal vein blocking. Results The L/M ratio was increased significantly (P<0.05) in PVC-45' and 60' groups than in SO group, with that of PVC-60' higher than that of PVC-45' group, but not significantly. Conclusion The increase of intestinal mucosal permeability after portal vein blocking is an early and important index for the damage of the intestinal mucosa barrier.
