ffect of early massive bronchoalveolar lavage on contralateral lung in dogs with acute serious smoke inhalation injury to unilateral lung
10.3321/j.issn:1000-5404.2001.04.006
- VernacularTitle:早期大容量肺灌洗对犬重度单肺吸入伤引起的对侧肺损害的影响
- Author:
Fa-Chuan NIE
1
;
Zong-Cheng YANG
;
Zhi-Yuan LIU
;
Qi-Zhi LUO
;
Yue-Sheng HUANG
Author Information
1. 第三军医大学附属西南医院
- From:Journal of Third Military Medical University
2001;23(4):390-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of acute serious smoke inhalation injury to unilateral lung on contralateral lung and the therapeutic efficacy of massive bronchoscopic lavage with saline to the primary injured bronchoalveolus at early stage after smoke inhalation on mitigating the secondary damage of the other lung and so as to confirm the therapeutic validity of lung lavage to smoke inhalation injury. Methods Fifteen mongrel dogs were insufflated with sawdust smoke into left lung and then randomized into 2 groups. The dogs in group A were maintained intravenous glucose saline transfusion and breathed air freely for 24 h after injury. Those in group B received a massive bronchoscopic lavage with 250 ml of saline to injured lung at 1 hour after injury and then were administrated similarly to those in group A. Gas exchange function of bilateral lungs in the process were observed and pathologic and phyiopathologic changes of the lung specimen were examined after the process. Results While the total lavaging volume was kept to 250 ml, the liquid volume remained in left lung after each operating was from 90 ml to 140 ml. All animals had a significant decline in pulmonary function after smoke inhalation injury. PaO2 in group B decreased significantly soon after the lavage and then increased gradually to exceeding that in group A. The left lung showed serious edema similarly in two groups but in right lung the water content was less, dynamic and static compliance was more in group B than in group A. Conclusion Bronchoalveolar massive lavage at early post-injury stage to injured lung after unilateral lung smoke inhalation injury can mitigate secondary damage of the non-injured lung. Lung lavage can decrease the intensity of secondary systemic inflammatory reaction and show a therapeutic validity to smoke inhalation injury.
