Effects of estrogen on neuron structure and expression of estrogen receptor in hypotha-lamus
10.3321/j.issn:1000-5404.2001.03.021
- VernacularTitle:雌激素对下丘脑神经元结构及雌激素受体表达水平的影响
- Author:
Qing CHANG
1
;
Da-Jun YING
;
Chang-Xu SHI
Author Information
1. Southwest Hospital Third Military Medical University
- From:Journal of Third Military Medical University
2001;23(3):318-320
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of ER-IR and the ultra structure in the medial preoptic area, arcuate nuclei of early-aged mice treated with estrogen. Methods Immunohistochemistry assay and electron microscopy were used in this study. Results ER-IR in the medical preoptic area and arcuate nuclei were greatly reduced after estrogen was given. The cell nuclei of neurons in these areas migrated towards the side, the nuclear membrane became folded, synapse became richer, and the number of synapse vesicle increased. Conclusion Estrogen can affect the neuron structure and function through the change of estrogen receptor expression in the medial preoptic area and arcuate nuclei of the hypothalamus cardiovascular center.
